Pedal Vasomotor Tone Following Aortofemoral Reconstructions

Aortofemoral thromboendarterectomy.

PURPOSE To study whether endarterectomy is feasible in all patients with aortofemoral atherosclerotic obstruction, considering early and late results. METHODS A clinical, prospective, and descriptive study carried out in a university hospital. Inclusion criteria were atherosclerotic aortofemoral obstructive disease, clinical status compatible with major surgery, and absence of prior restorati...

Nitroso-redox balance in control of coronary vasomotor tone.

Reactive oxygen species (ROS) are essential in vascular homeostasis but may contribute to vascular dysfunction when excessively produced. Superoxide anion (O(2)(·-)) can directly affect vascular tone by reacting with K(+) channels and indirectly by reacting with nitric oxide (NO), thereby scavenging NO and causing nitroso-redox imbalance. After myocardial infarction (MI), oxidative stress incre...

Alterations in flow-dependent vasomotor tone in spontaneously hypertensive rats.

We studied the effect of endothelium on the flow-induced response of conductance arteries and the resistance arteriolar network in an in situ model of perfused mesenteric artery in normotensive Wistar-Kyoto and spontaneously hypertensive rats. The mesenteric network was perfused with a Tyrode's albumin solution. The diameter of a conductance mesenteric artery was measured using a video camera s...

Control and Coordination of Vasomotor Tone in the Microcirculation

Genetic determinants of coronary vasomotor tone in humans.

APART FROM AND IN ADDITION to all established mechanisms and mediators in the regulation of coronary blood flow under normal and pathological circumstances (1), there remains substantial interindividual variability in coronary vasomotor responses, both in the experimental animal and in humans. Such interindividual variability has, among other factors such as age, diet, and environmental factors...